Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety

Abstract
Liraglutide and other agonists of the glucagon-like peptide 1 receptor (GLP-1RAs) are effective weight loss drugs, but how they suppress appetite remains unclear. GLP-1RAs inhibit hunger-promoting Agouti-related peptide (AgRP) neurons of the arcuate hypothalamus (Arc) but only indirectly, implicating synaptic afferents to AgRP neurons. 

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Addison N Webster, Jordan J Becker, Chia Li, Dana C Schwalbe, Damien Kerspern, Eva O Karolczak, Elizabeth N Godschall, Dylan Matthew Belmont-Rausch, Tune H Pers, Andrew Lutas, Naomi Habib, Ali D Güler, Michael J Krashes, John N Campbell
https://pubmed.ncbi.nlm.nih.gov/37961449/