Localization, induction, and cellular effects of tau phosphorylated at threonine 217

Introduction: Tau phosphorylation at T217 is a promising Alzheimer's disease (AD) biomarker, but its functional consequences were unknown.

Methods: Human brain and cultured mouse neurons were analyzed by immunoblotting and immunofluorescence for total tau, taupT217 , taupT181 , taupT231 , and taupS396/pS404.

Results: In the brain, taupT217 appears in neurons at Braak stages I and II, becomes more prevalent later, and co-localizes partially with other phospho-tau epitopes.

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Binita Rajbanshi, Anuj Guruacharya, James W Mandell, George S Bloom 
https://pubmed.ncbi.nlm.nih.gov/36633254/