Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APPSAA knock-in mouse model of Alzheimer's disease

Abstract Introduction: Reduced brain energy metabolism, mammalian target of rapamycin (mTOR) dysregulation, and extracellular amyloid beta (Aβ) oligomer (xcAβO) buildup are some well-known Alzheimer's disease (AD) features; how they promote neurodegeneration is poorly understood. Read More

Andrés Norambuena, Vijay Kumar Sagar, Zhuoying Wang, Prakash Raut, Ziang Feng, Horst Wallrabe, Evelyn Pardo, Taylor Kim, Shagufta Rehman Alam, Song Hu, Ammasi Periasamy, George S Bloom
https://pubmed.ncbi.nlm.nih.gov/39171353/