UVA Biology People Sarah Siegrist

Sarah Siegrist

Associate Professor of Biology
Gilmer 413
(434) 982-2604
Lab: (434) 243-4328


  • B.S. Miami University, Oxford Ohio
  • PhD University of Oregon, Eugene, OR

Research Interests

In the Siegrist Lab, we are working to understand how the immense number of molecularly and functionally distinct neuron types are produced during development and importantly, how natural environments impact generation of neuron number and diversity in animals living in the real world. Research in the Siegrist lab is focused on the following fundamental themes.

1) Nutrient-dependent control of neural stem cells in their niche

2) Intrinsic genetic programs and temporal identity factors that control neural stem cell proliferation timing and neuronal diversity

3) Neural circuits involved in nutrient sensing and brain growth control

Representative Publications

  • Yuan, X., Sipe, C.W., Suzawa, M., Bland, M.L., and Siegrist, S.E. (2020) Dilp-2 mediated PI3-kinase activation coordinates reactivation of quiescent neuroblasts with growth of their glial stem cell niche. PLOS Biology, May 28;18(5).
  • Pahl, M.C., Doyle, S.E., and Siegrist, S.E. (2019) E93 integrates neuroblast intrinsic state with developmental time to terminate neurogenesis via autophagy. Current Biology, Mar 4;29(5).
  • Sipe, C.W., and Siegrist, S.E. (2017) Eyeless uncouples mushroom body neuroblast proliferation from dietary amino acids in Drosophila. eLIFE Aug 9;6.
  • Doyle, S.E., Pahl, M.C., Siller K.H., Ardiff, L, and Siegrist, S.E. (2017) Neuroblast niche position is controlled by Phosphoinositide 3-kinase-dependent DE-Cadherin adhesion. Development Mar 1;144(5):820-829.