- B.S., University of California, Santa Barbara, 2000
- Ph.D., Johns Hopkins Medical Institute, 2007
- Postdoc, Johns Hopkins Medical Institute, 2007-2008
- Postdoc, University of Washington, 2008-2013
Research in the Güler Malaria Lab focuses on the human-infective malaria parasite, Plasmodium falciparum. Some of our projects are described below:
· We are interested in underlying mechanisms that drive genetic change in parasites during the development of antimalarial resistance. Our studies in this area utilize a range of cellular, biochemical and molecular techniques to uncover pathways that are important for this process.
· Some genetic alterations that arise during antimalarial exposure drive metabolic adaptation in the parasite. By employing metabolite profiling paired with computational modeling to investigate these slight adjustments, we aim to reveal unique pathways that enhance parasite survival.
· We partner with researchers in malaria endemic countries to apply our predictions from lab-based models to investigations with patient-isolated parasites. These studies inform our knowledge of general parasite adaptation and its effect on disease severity. For more information, please visit the Güler Malaria Lab Website.
1. McDaniels JM, Huckaby AC, Carter SA, Lingeman S, Francis A, Congdon M, Santos W, Rathod PK, Guler JL (2020). Extra-chromosomal DNA amplicons in antimalarial resistant Plasmodium falciparum. Molecular Microbiology. Read publication
Brown AC, Guler JL (2020). From circulation to cultivation: Plasmodium in vivo versus in vitro. Trends in Parasitology. Read publication
Brown AC, Moore CC, Guler JL (2020). Cholesterol-dependent enrichment of understudied erythrocytic stages of human Plasmodium parasites. Scientific Reports. Mar 12;10(1):4591. PMCID: PMC7067793.
Untaroiu AM, Carey MA, Guler JL*, Papin JA* (2019). Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies. BMC Bioinformatics. Apr 15;20(1):186. Read publication (* denotes co-corresponding authors)
Huckaby AC, Granum CS, Carey, MA, Szlachta K, Al-Barghouthi B, Wang YH, Guler JL (2019). Complex DNA structures trigger copy number variation across the Plasmodium falciparum genome. Nucleic Acids Research. Feb 28;47(4):1615-1627. PMCID:PMC6393310
Carey MA, Covelli V, Brown A, Medlock G, Haaren M, Cooper J, Papin J, Guler JL (2018). Influential parameters for the analysis of intracellular parasite metabolomics. mSphere. Apr 18;3(2). PMCID:PMC5907652.
Carey MA, Papin JA*, Guler JL* (2017). Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance. BMC Genomics. Jul 19;18(1):543. PMCID:PMC5518114. (*) denotes co-corresponding authors.
Kassaza K, Operario DJ, Nyehangane D, Coffey C, Namugosa M, Turkheimer L, Ojuka P, Orikiriza P, Mwanga-Amumpaire J, Byarugaba F, Bazira J, Guler JL, Moore CC, Boum Y. Detection of Plasmodium species by high resolution melt analysis of DNA from blood smears acquired in Southwestern Uganda. Journal of Clinical Microbiology. 2017 Dec 26;56(1). pii: e01060-17. doi: 10.1128/JCM.01060-17.
- Pholwat, S., Liu, J., Stroup, S., Jacob, S., Banura, P., Moore, C., Huang, F., Laufer, M., Houpt, E., Güler, J. The Malaria TaqMan Array Card: 87 assays for Plasmodium falciparum drug resistance, speciation, and genotyping in a single reaction.. Antimicrob Agents Chemother. 2017 Mar 6. pii: AAC.00110-17. doi:10.1128/AAC.00110-17.