Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network
Salient cues, such as the rising sun or availability of food, entrain biological clocks for behavioral adaptation. The mechanisms underlying entrainment to food availability remain elusive. Using single-nucleus RNA sequencing during scheduled feeding, we identified a dorsomedial hypothalamus leptin receptor-expressing (DMHLepR) neuron population that up-regulates circadian entrainment genes and exhibits calcium activity before an anticipated meal. Click here, to read full publication.
Qijun Tang, Elizabeth Godschall, Charles D Brennan, Qi Zhang, Ruei-Jen Abraham-Fan, Sydney P Williams, Taha Buğra Güngül, Roberta Onoharigho, Aleyna Buyukaksakal, Ricardo Salinas, Isabelle R Sajonia, Joey J Olivieri, O Yipkin Calhan, Christopher D Deppmann, John N Campbell, Brandon Podyma, Ali D Güler