Paul Adler

William R. Kenan, Jr. Professor of Biology
420 PLSB
(434) 982-5475
Lab: (434) 982-5476

Education

  • B.A., Carnegie Mellon University, 1969
  • M.A., Boston University, 1971
  • Ph.D., Massachusetts Institute of Technology, 1975
  • Postdoctoral Research, University of California, Irvine, 1975-77

Research Interests

Research in the Adler lab is focused on aspects of cell and tissue polarity. For many years we have studied planar polarity using the wing of Drosophila as a model system. This tissue polarity is manifested by each cell in the wing forming a distally pointing hair. Early work from the lab established that a genetic regulatory pathway (the frizzled pathway) controlled this by restricting the activation of the cytoskseleton to grow the hair to the most distal part of the cell. Work from a number of laboratories has shown that the proteins encoded by frizzled pathway genes accumulate in protein complexes located on either the proximal or distal sides of wing cells. In recent years our research has primarily been focused on downstream members of the pathway, such as friz, inturned and multiple wing hairs and how these proteins interact and function to locally activate the cytoskeleton.

Insect cuticle is a multilayered structure whose physical properties vary more than any other biological material.  We have recently begun to examine the genetic basis for the formation of insect cuticle.  Our initial results have suggested that the outmost envelope layer, which is deposited first instructs the deposition of later layers.   

Representative Publications

  • Nagaraj, P. And P. N. Adler (2012).  Dusky-like functions as a Rab11 effector for the deposition of cuticle during Drosophila bristle development.  Development 139:906-916. PMID: 22278919; PMCID: PMC3274354.
  • Adler, P.N., Sobala, L., Thom, D. and R. Nagaraj (2013). dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing. Developmental Biology 379:76–91. PMID: 23623898; PMCID: PMC3686509.
  • Wang, Y., J. Yan, H. Lee, Lu, Q and P. N. Adler (2014).  The proteins encoded by the Drosophila Planar Polarity Effector genes inturned, fuzzy and fritz interact physically and can re-pattern the accumulation of “upstream” Planar Cell Polarity proteins.  Developmental Biology 394: 156-169.   PMID: 25072625; PMC4163512.
  • Qiuheng, L., Schafer, D. A. and P. N. Adler (2015). The Drosophila planar polarity gene multiple wing hairs directly regulates the actin cytoskeleton.  Development, 142:2478-2486. PMID:26153232; PMCID, in progress.
  • Qiuheng L. and P. N. Adler (2015).  The diaphanous gene of Drosophila interacts antagonistically with multiple wing hairs and plays a key role in wing hair morphogenesis. Plos One 10(3): e0115623. PMID: 25730111; PMCID: PMC4346269.
  • Sobala, L. F., Wang, Y. and P. N. Adler (2015).  ChtVis-Tomato, a fluorescent reporter for in vivo visualization of chitin deposition in Drosophila.  Development, 142:3974-3981.