- B.A., Northwestern University, 1971
- Ph.D., Brandeis University, 1976
- Postdoc Research, California Inst. of Technology, 1976-1979
We study behavioral roles of biogenic amine neurotransmitters in the fruit fly, Drosophila melanogaster. These transmitters, including the well-studied molecules dopamine and serotonin, have roles in the fly that parallel those found in higher animals, validating use of this important genetic model. We study these roles with pharmacological, physiological and genetic approaches. Drugs such as aerosolized free base cocaine directly target this system, and can be used as probes to study its state in vivo.
We have developed a new model fly lacking dopamine in the brain. The laboratory is now critically focussed on an unexpected finding from these flies: on backcrossing, a sub-line of these flies regained surprisingly normal levels of locomotion, a phenotype we are calling ‘dopamine bypass’. We are using multiple approaches to identify the genes required for this dopamine bypass phenotype. These genes may be of relevance to human diseases such as Parkinson’s Disease, where loss of dopamine neurons results in serious motor and cognitive issues. In addition, we are using the dopamine deficient flies to study behavioral roles of dopamine neuron subsets by selective restoration of dopamine.