- B.A., University of Pennsylvania, 1973
- Ph.D., University of Pennsylvania, 1979
Research in our laboratory is now focused primarily on Alzheimer’s disease (AD). The histopathological hallmark of AD is the presence in brain of extracellular plaques of ß-amyloid peptide fibrils, and intraneuronal neurofibrillary tangles, which are filaments composed of the protein, tau. Despite the conspicuous appearance of plaques and tangles, a growing body of evidence points to their building blocks, ß-amyloid and tau oligomers, as being the toxic molecular species that cause AD. For example, we have found that tau expression is required for several adverse effects of ß-amyloid oligomers on neurons, including microtubules loss, ectopic re-rentry into the cell cycle and cytotoxicity. The goals of our work are to decipher the metabolic links that connect ß-amyloid and tau to damage neurons, to define the structures and pathological properties of various types of ß-amyloid and tau oligomers, and to develop effective therapeutic and diagnostic tools for AD.
For more information about research interests, visit my lab website.
- Norambuena, A., Wallrabe, H., McMahon, L., Silva, A., Swanson, E., Thomas, S,. Baerthlein, D., Kodis, E., Oddo, S., Mandell, J.W. and Bloom, G.S. (2017). mTOR and neuronal cell cycle reentry:How Impaired Brain Insulin Signaling Promotes Alzheimer’s Disease. Alzheimer’s & Dementia, 13: 152-167.
- Sharlow, E.R., Leimgruber, S., Lira, A., McConnell, M.J., Saucerman, J.J., Brautigan, D.L., Kubicka, E., Norambuena, A., Bloom, G.S., Epperly, M.W., Greenberger, J.S. and Lazo, J.S. (2016). A small molecule screen exposes mTOR signaling pathway involvement in radiation-induced apoptosis. ACS Chemical Biology, 11: 1428-1437.
- Khan, S.S. and Bloom, G.S. (2016). Tau: The Center of a Signaling Nexus in Alzheimer’s Disease. Frontiers in Neuroscience, 10: article 31. PMCID: PMC4746348.
- Fang, X., Bianhong, Z., Thisse, B., Bloom, G.S. and Thisse, C. (2015). IQGAP3 Is Essential for Cell Proliferation and Motility During Zebrafish Embryonic Development. Cytoskeleton 72: 422-433. PMCID: PMC4600665.
- Marbiah, M., Harvey, A., West, B., Louzolo, A., Banerjee, P., Alden, J., Grigoriadis, A., Hummerich, H., Kan, H-M., Cai, Y., Bloom, G.S., Parmjit, J., Collinge, J. and Klöhn, P-C. (2014). Identification of a Gene Regulatory Network Associated with Prion Replication. EMBO Journal, 33: 1527-1547. PMCID:PMC4198050.
- Bloom, G.S. (2014). Amyloid and Tau: the Trigger and Bullet in Alzheimer's Disease Pathogenesis JAMA Neurology, 71: 505-508. PMCID-in process.
- Wallrabe, H., Cai, Y., Sun, Y., Perisasamy, A., Schafer, D.A., Kan, H-M., Pereira, R.L., and Bloom, G.S. (2013). IQGAP1 Interactome Analysis by In Vitro Reconstitution and Live Cell 3-Color FRET Microscopy. Cytoskeleton, 70: 819-836. PMCID: PMC3917506.