David Parichy

Pratt-Ivy Foundation Distinguished Professor of Morphogenesis

Education

• B.A., Reed College, 1991

• Ph.D., Population Biology, University of California at Davis, 1997

• Postdoctoral, Washington University Medical School, 1997–2000

 

Research Interests

Our research program seeks to answer a variety of questions having both basic and translational relevance. Current efforts focus on: 

• long-distance communication by specialized cellular projections
• intersections of hormonal controls with local mechanisms of differentiation and morphogenesis
• establishment and recruitment of post-embryonic stem cells during development and regeneration
• molecular and cellular bases for the evolutionary diversification of adult form

Much of our work uses zebrafish and related species, and emphasizes pigmentation, pigment cells, and their neural crest progenitors. Additional efforts focus on mechanisms of melanoma progression, development and regeneration of scales and skin in zebrafish, and appendage regeneration in salamanders. 


Adult pigment cells in magritte mutant zebrafish

Past areas of research have included genetic controls of post-embryonic development and metamorphosis; behavioral significance of pigment pattern variation; molecular and endocrine factors in skeletogenesis and kidney function; zebrafish natural history in India; and pigment pattern development and evolution in amphibians. The lab has diverse interests and we are always happy to entertain new ideas. We welcome postdoctoral scholars, graduate students and undergraduates. For more information please see our website.

The lab will be coming to the University of Virginia in Summer 2017.

Representative Publications

  • Eom DS, Parichy DM. 2017. A macrophage relay for long distance signaling during post-embryonic tissue remodeling. Science doi:10.1126/science.aal2745.

  • Eom DS, Bain EJ, Patterson LB, Grout ME, Parichy DM. 2015. Long-distance communication by specialized cellular projections during pigment pattern development and evolution. eLife 10.7554/eLife.12401.

  • McMenamin SK, Bain EJ, McCann AE, Patterson LB, Eom DS, Waller ZP, Hamill JC, Kuhlman JA, Eisen JS, Parichy DM. 2014. Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. Science 345:1358–1361. 
     
  • Patterson LB, Bain EJ, Parichy DM. 2014. Pigment cell interactions and differential xanthophore recruitment underlying zebrafish stripe reiteration and Danio pattern evolution. Nature Communications 5:6299.
     
  • Patterson LB, Parichy DM. 2013. Interactions with iridophores and the tissue environment required for patterning melanophores and xanthophores during zebrafish adult pigment stripe formation. PLoS Genetics 9:e100356.
     
  • Parichy DM, Elizondo MR, Mills MG, Gordon TN, Engeszer RE. 2009. Normal table of post-embryonic zebrafish development: staging by externally visible anatomy of the living fish. Developmental Dynamics 238:2975–3015. 
     
  • Engeszer RE, Wang G, Ryan MJ, Parichy DM. 2008. Sex-specific perceptual space for a vertebrate basal social aggregative behavior. Proc. Natl Acad. Sci. USA 105:929–933.
     
  • Elizondo MR, Arduini BL, Paulsen J, Macdonald EL, Sabel JL, Henion PD, Cornell RA, Parichy DM. 2005. Defective skeletogenesis with kidney stone formation in dwarf zebrafish mutant for trpm7Current Biology 15:667–671.