Office Address: 204 PLSB

Education

Ph.D., Biology & Biomedical Sciences, Washington University, St. Louis, MO, 1993
BA, Biology, St. Olaf College, Northfield, MN, 1987

Research Interests

• Pedagogical innovation in undergraduate biology
• Mechanisms of viral immune evasion
• Discovery of human T cell tumor antigens and translation to experimental vaccines/clinical trials

Courses:

Current UVA Courses

• Biol 2100, Introduction to Biology with Laboratory: Cell Biology and Genetics
• Biol 3270, General Microbiology with Laboratory (instructor of lab component)
• Biol 3240, Introduction to Immunology
• Biol 4390, Biological Therapy of Cancer
• Cola 1500, Why Haven’t We Cured Cancer?

Representative Publications

Slingluff, C.L. Jr. Yamshchikov, G., Neese, P. Galavotti, H., Eastham, S., Engelhard, VH., Kittlesen, D., Deacon, D., Hibbitts, S., Grosh, WW., Petroni, G., Cohen, R., Wiernasz, C., Patterson, J.W., Conway, B.P., Ross, W.G. (2001). Phase I trial of a melanoma vaccine with gp100(280-288) peptide and tetanus helper peptide in adjuvant: immunologic and clinical outcomes. Clinical Cancer Research, 7(10):3012-24.

Slingluff, C.L. Jr., Colella, T.A., Thompson, L., Graham, D.D., Skipper, J.C., Caldwell, J., Brinckerhoff, L., Kittlesen, D.J., Deacon, D.H., Oei, C., Harthun, N.L., Huczko, E.L., Hunt, D.F., Darrow, T.L., Engelhard, V.H., (2000). Melanomas with concordant loss of multiple melanocytic differentiation proteins: immune escape that may be overcome by targeting unique or undefined antigens. Cancer Immunology, Immunotherapy, 48(12):661-72.

Yang, S., Kittlesen, D., Slingluff, C.L. Jr., Vervaert ,C.E., Seigler, H.F., Darrow T.L. (2000). Dendritic cells infected with a vaccinia vector carrying the human gp100 gene simultaneously present multiple specificities and elicit high-affinity T cells reactive to multiple epitopes and restricted by HLA-A2 and -A3. Journal of Immunology, 164(8):4204-11.

Kittlesen, D.J., Chianese-Bullock, K.A., Yao, Z.Q., Braciale, T.J., Hahn, YS., (2000). Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. Journal of Clinical Investigation, 106(10):1239-49.