Jenny Güler’s Lab Publishes New Research on Malaria

August 1, 2017

Congratulations to the Department of Biology’s Dr. Jenny Güler and her team of researchers, who were recently published in BMC Genomics. Their paper, “Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance,” focuses on the threat of malaria.  According to Dr. Güler, malaria remains a major public health burden and resistance has emerged to every drug on the market. To increase our understanding about how the malaria parasite responds to stress, we used a systems biology approach to compare metabolism from sensitive and resistant parasites. Using this analysis, we uncovered that resistant parasites maintain greater metabolic flexibility and identified specific metabolic shifts that can be targeted to limit resistance development.” 

To read the full text, click here.  For more information on Dr. Güler’s lab, please visit her lab webpage.