The Department of Biology’s Dr. George Bloom, and his lab, have published a new paper entitled, “mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer’s disease.” This study, which was led by Dr. Andrés Norambuena in the Bloom lab, details a complex cellular signalling pathway that causes neurons to re-enter the cell cycle and eventually die in Alzheimer’s disease (AD). The study also explains why brain insulin resistance, which is a characteristic feature of AD brain, enables this mechanism for neuron death in AD.
The entire paper can be read by clicking here.
Interested in learning more about the Bloom lab? Visit their website!